These are the Billboard magazine Hot Dance Club Play number one hits of 2001.
| Issue date | Song | Artist | Reference(s) |
|---|---|---|---|
| January 6 | "One More Time" | Daft Punk | [1] |
| January 13 | "The Underground" | Celeda | [2] |
| January 20 | "Don't Tell Me" | Madonna | [3] |
| January 27 | "Lady (Hear Me Tonight)" | Modjo | [4] |
| February 3 | "Beautiful Day" | U2 | [5] |
| February 10 | "Lovin' You" | Kristine W | [6] |
| February 17 | "Boy" | Book of Love | [7] |
| February 24 | "Papa's Got a Brand New Pigbag" | Thunderpuss | [8] |
| March 3 | "Stranger in My House" | Tamia | [9] |
| March 10 | "Who the Hell Are You" | Madison Avenue | [10] |
| March 17 | "Needin' U II" | David Morales presents The Face featuring Juliet Roberts | [11] |
| March 24 | "Just Keep Thinking About You" | Gloria Gaynor | [12] |
| March 31 | "The Power" | Rosabel featuring Jeanie Tracy | [13] |
| April 7 | "Mine to Give" | Photek featuring Robert Owens | [14] |
| April 14 | "Is It Love?" | Chili Hi Fly | [15] |
| April 21 | "Looking for Love" | Karen Ramirez | [16] |
| April 28 | "Are You Satisfied" | Victor Calderone featuring Deborah Cooper | [17] |
| May 5 | [18] | ||
| May 12 | "All for You" | Janet | [19] |
| May 19 | [20] | ||
| May 26 | [21] | ||
| June 2 | "What It Feels Like for a Girl" | Madonna | [22] |
| June 9 | "Dream On" | Depeche Mode | [23] |
| June 16 | "Get It Up (The Feeling)" | Ultra Naté | [24] |
| June 23 | [25] | ||
| June 30 | "You're the Worst Thing for Me" | Pusaka featuring Thea Austin | [26] |
| July 7 | "Bumpin' and Jumpin'" | Kim English | [27] |
| July 14 | "Keep Control" | Sono | [28] |
| July 21 | [29] | ||
| July 28 | [30] | ||
| August 4 | [31] | ||
| August 11 | "Planets of the Universe" | Stevie Nicks | [32] |
| August 18 | "Someone to Call My Lover" | Janet | [33] |
| August 25 | "You Set Me Free" | Abigail | [34] |
| September 1 | "Thank You" | Dido | [35] |
| September 8 | "I Feel Loved" | Depeche Mode | [36] |
| September 15 | [37] | ||
| September 22 | "Absolutely Not" | Deborah Cox | [38] |
| September 29 | [39] | ||
| October 6 | "Stand Still" | Aubrey | [40] |
| October 13 | "Feel This 2001" | Robbie Rivera | [41] |
| October 20 | "Crystal" | New Order | [42] |
| October 27 | "Yes!" | Amber | [43] |
| November 3 | "It Began in Afrika" | The Chemical Brothers | [44] |
| November 10 | "Break 4 Love" | Peter Rauhofer + Pet Shop Boys = The Collaboration | [45] |
| November 17 | "Impressive Instant" | Madonna | [46] |
| November 24 | [47] | ||
| December 1 | "So Strong" | Ben Shaw featuring Adele Holness | [48] |
| December 8 | "Lettin' Ya Mind Go" | Desert | [49] |
| December 15 | "Hero" | Enrique Iglesias | [50] |
| December 22 | "Turn off the Light" | Nelly Furtado | [51] |
| December 29 | "Come on Down" | Crystal Waters | [52] |
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